Scabies is an ancient disease (documented as far back as 2500 years ago). It affects about 300 million people annually worldwide, and the prevalence is as high as about 60 % of Indigenous and Torres Strait Islander children in Australia. This is more than six times the rate seen in the rest of the developed world. Scabies is frequently complicated by bacterial infection leading to the development of skin sores and other more serious consequences such as septicemia and chronic heart and kidney diseases. This causes a substantial social and economic burden especially in resource poor communities around the world.
A research made in 2013 entitled: “Scabies Increased the Risk of Chronic Kidney Disease: A 5-Year Follow-Up Study” aimed to investigate the risk of Chronic Kidney Disease (CKD) subsequent to scabies making use of a population-based dataset in Taiwan. Initially, the most documented complication of scabies has been reported to be infection by group A streptococci, which has in turn been suggested to contribute to the development of glomerulonephritis. The researchers used matched-cohort study that included 5,071 subjects with scabies and 25,355 randomly selected comparison subjects, who they individually observed for a 5-year period in order to identify those who subsequently received a diagnosis of CKD during the follow-up period. During the period of the study, Stratified Cox proportional hazards regressions were performed to compute the hazard ratio (HR) of CKD. After several years, the researchers came to understand that the incidence rate of CKD was 9.66 (8.51-10.93) per 1,000 person-years and 6.24 (5.82-6.69) per 1000 person-years for subjects with and without scabies respectively. The HR for CKD for the subjects with scabies was 1.34 (95% CI = 1.15-1.56) that of comparison subjects after adjusting for monthly income, hypertension, diabetes, obesity, stroke, coronary heart disease, chronic obstructive pulmonary disease, tobacco use disorder, hyperlipidemia and alcohol abuse during the study period. Male subjects with scabies were 1.40 (95% CI = 1.14-1.71) times more likely than comparison subjects to suffer from subsequent CKD, and female study subjects were 1.27 (95% CI = 1.05-1.61) times more likely. As the results of their research suggest, they concluded that there is an increased risk for CKD among patients suffering from scabies.
(© 2013 The Authors Journal of the European Academy of Dermatology and Venereology)
According to World Health Organization (WHO), over 130 Million people around the world can be affected by Scabies at any time. So, they have suggested that one of the most effective ways to manage it is by applying topical scabicides such as Permethrin(5%), formulated in Pharmaceutical products like Lyderm. Lyderm Topical Cream is the leading choice of most Dermatologists in different countries in treating Scabies because it contains a potent ingredient called Permethrin 5% this sentence seems like repeated that works directly at the source of scabies, killing the parasitic mite that causes scabies. It is a widely used synthetic pyrethroid insecticide whose parent compound was originally derived from chrysanthemums. It is well tolerated, has low toxicity, is poorly absorbed across the skin, and the small percentage that is absorbed is rapidly metabolized. A single overnight application is equally as effective as lindane.
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© 2013 The Authors Journal of the European Academy of Dermatology and Venereology
© 2013 European Academy of Dermatology and Venereology
© 2015 Thomas et al. BioMed Central Ltd. Retrieved from https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-015-0983-z
BMC Infect Dis., (2015). NCBI: Scabies: an ancient global disease with a need for new therapies. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487193/
World Health Organization, (2017). Lymphatic filariasis: Scabies. Retrieved from: http://www.who.int/lymphatic_filariasis/epidemiology/scabies/en/